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SYSTEM ARCHITECTURE V1.0

The Anhydrous Protocol.

Overcoming the hydrolytic degradation of anthocyanins via supramolecular solvent engineering. A shift from aqueous dissolution to Deep Eutectic suspension.

TARGET MOLECULE

Cyanidin-3-Glucoside

DELIVERY VEHICLE

Deep Eutectic Solvent (DES)

PATENT STATUS

Pending (US 63/950,692)

01. THE SUBSTRATE

The Most Potent Radical Scavenger.

Cyanidin-3-Glucoside (C3G) possesses the highest Oxygen Radical Absorbance Capacity (ORAC) of the flavonoid family. However, its flavylium cation structure is inherently unstable in water (pH > 4.5), leading to rapid hydration and loss of color (pseudobase formation).


The Challenge: Traditional skincare formulations are 70-80% water. This renders C3G inactive within days of bottling.


FIG 1.1: FLAVYLIUM CATION

02. THE VEHICLE

Deep Eutectic Systems (DES).

We utilize a binary system of hydrogen-bond donors and acceptors that form a eutectic liquid at room temperature. This creates a water-free solvent cage that mimics the intracellular environment of a plant during drought stress.

0.23

WATER ACTIVITY (Aw)

Below the threshold for hydrolytic oxidation.

<500nm

PARTICLE SIZE

High-shear homogenized vesicular dispersion.

100%

BIOAVAILABILITY

Instant solubilization upon skin contact.

03. STABILITY ASSAY

Comparative Retention Kinetics.

Accelerated aging analysis (40°C / 75% RH) demonstrating C3G retention over a 12-month equivalent period.

AQUEOUS SERUM (0% Retention)


ANTHOS DES (>95% Retention)

RETENTION (%)

TIME (MONTHS)

ANTHOS BIO

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SYSTEM STATUS: NOMINAL